8 research outputs found

    Enthalten die Stellungnahmen der NPD-Fraktion im Plenum des sächsischen Landesparlamentes rechtsextremistische Elemente?: Eine qualitative Inhaltsanalyse der Plenarprotokolle aus der 4. Legislaturperiode des Sächsischen Landtages

    Get PDF
    Die Arbeit untersucht die Stellungnahmen der NPD-Fraktion im Sächsischen Landtag auf rechtsextremistische Inhalte. Dafür werden die entsprechenden Abschnitte der Plenarprotokolle aus dem ersten Teil der 4. Legislaturperiode (Oktober 2004 bis Juli 2006) mittels einer qualitativen Inhaltsanalyse untersucht

    Targeting cardiomyocyte ADAM10 ectodomain shedding promotes survival early after myocardial infarction

    Get PDF
    After myocardial infarction the innate immune response is pivotal in clearing of tissue debris as well as scar formation, but exaggerated cytokine and chemokine secretion with subsequent leukocyte infiltration also leads to further tissue damage. Here, we address the value of targeting a previously unknown a disintegrin and metalloprotease 10 (ADAM10)/CX3CL1 axis in the regulation of neutrophil recruitment early after MI. We show that myocardial ADAM10 is distinctly upregulated in myocardial biopsies from patients with ischemia-driven cardiomyopathy. Intriguingly, upon MI in mice, pharmacological ADAM10 inhibition as well as genetic cardiomycyte-specific ADAM10 deletion improves survival with markedly enhanced heart function and reduced scar size. Mechanistically, abolished ADAM10-mediated CX3CL1 ectodomain shedding leads to diminished IL-1β-dependent inflammation, reduced neutrophil bone marrow egress as well as myocardial tissue infiltration. Thus, our data shows a conceptual insight into how acute MI induces chemotactic signaling via ectodomain shedding in cardiomyocytes

    Enthalten die Stellungnahmen der NPD-Fraktion im Plenum des sächsischen Landesparlamentes rechtsextremistische Elemente?: Eine qualitative Inhaltsanalyse der Plenarprotokolle aus der 4. Legislaturperiode des Sächsischen Landtages

    Get PDF
    Die Arbeit untersucht die Stellungnahmen der NPD-Fraktion im Sächsischen Landtag auf rechtsextremistische Inhalte. Dafür werden die entsprechenden Abschnitte der Plenarprotokolle aus dem ersten Teil der 4. Legislaturperiode (Oktober 2004 bis Juli 2006) mittels einer qualitativen Inhaltsanalyse untersucht

    Enthalten die Stellungnahmen der NPD-Fraktion im Plenum des sächsischen Landesparlamentes rechtsextremistische Elemente? Eine qualitative Inhaltsanalyse der Plenarprotokolle aus der 4. Legislaturperiode des Sächsischen Landtages

    No full text
    Die Arbeit untersucht die Stellungnahmen der NPD-Fraktion im Sächsischen Landtag auf rechtsextremistische Inhalte. Dafür werden die entsprechenden Abschnitte der Plenarprotokolle aus dem ersten Teil der 4. Legislaturperiode (Oktober 2004 bis Juli 2006) mittels einer qualitativen Inhaltsanalyse untersucht

    Voice processing and voice-identity recognition

    No full text
    The human voice is the most important sound source in our environment, not only because it produces speech, but also because it conveys information about the speaker. In many situations, listeners understand the speech message and recognize the speaker with minimal effort. Psychophysical studies have investigated which voice qualities (such as vocal timbre) distinguish speakers and allow listeners to recognize speakers. Glottal and vocal tract characteristics strongly influence perceived similarity between speakers and serve as cues for voice-identity recognition. However, the importance of a particular voice quality for voice-identity recognition depends on the speaker and the stimulus. Voice-identity recognition relies on a network of brain regions comprising a core system of auditory regions within the temporal lobe (including regions dedicated to processing glottal and vocal tract characteristics and regions that play more abstract roles) and an extended system of nonauditory regions representing information associated with specific voice identities (e.g., faces and names). This brain network is supported by early, direct connections between the core voice system and an analogous core face system. Precisely how all these brain regions work together to accomplish voice-identity recognition remains an open question; answering it will require rigorous testing of hypotheses derived from theoretical accounts of voice processing

    Neuroscience-driven discovery and development of sleep therapeutics

    No full text

    Lasers and Coherent Light Sources

    No full text
    corecore